I really like your work and will translate this article, too. One thing i see differently is the existence of a pandemie by old definition as having a lot of deaths. In Germany in 2020 less people died than expected and hospitals were equally full as every year. I cannot find a single dataset that would tell me there was a killer virus in Germany in 2020 or 2021. And as you say the NPIs are not responsible for that. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0255540
It is so important that we speak truth, not skew data or report mis-information in fear of "vaccine hesitancy" or "Hospitals being over-run".
Nearly all hospitals in Australia were over-run pre-pandemic - all this virus has done is showcase that.
Conversation regarding building our immunity & better health systems never make it to the mainstream media because of aforementioned "fears", this has to stop if we are going to survive, especially the working class and poor.
This particular paragraph from the aforementioned article on mucosal immunity grab my attention and led me to conclude the anti-SARS-CoV-2 lasting immune cells elicited by the vaccines wouldn't know to migrate to the lung tissue and at the portals of pathogen entry after administration of the vaccines: "Paired studies of respiratory wash and blood samples in severe COVID-19 showed activated TRM T cells in the airways that do not correlate with systemic blood T cell responses, clearly suggesting that tissues, rather than blood, are where anti-SARS-CoV-2 lasting immune cells act [6]. Likewise, specific lung-resident memory B cells are formed early at the portals of pathogen entry following mucosal infection, and provide better protection than circulating memory cells."
Since biology is not my area of expertise, I was hoping one day to have an expert confirmed my hypothesis/educated guess. Again thank you very much for sharing your knowledge.
Wow. You made a complex concept understandable. And I STILL think you're a really smart guy.... and someone who understands the value of communication over academic prose. Thank you sir, this one's saved for future reference and education!
A question: is this analysis of the different types of immunity, & the effects of vaccines on immunity, in any way affected (or potentially affected) by recent observations from the UK Health Security Agency surveillance data that N antibody levels appear to be lower in individuals who acquire infection following 2 doses of vaccination? (Page 23 of week 42 UKHSA vaccine surveillance report, comments on Table 6.)
Thank you for this. It’s the most in-depth description I’ve found! Do you think there is any advantage in one dose of vaccine following confirmed infection and recovery?
Thank you, I think the next step would be to introduce the offsetting risks associated with the new technology as its clear there are numerous injuries and deaths, many of which (the majority) are not reported accurately, or hidden. Then we start seeing the wood for the trees.
Thanks for the piece of "natural immunity" versus vaccination. Although your hunch has been that "natural immunity" should be more efficacious, this does not seem to square with the recent paper published in Science entitled "mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern."
I think you're absolutely right that we should take into account natural immunity (from prior infection) when assessing the current state of the pandemic. But that's different from using natural immunity as a strategy, right? Clearly, many, many more people would have become severely sick or died without the vaccines.
Also: more recent work suggests that the vaccine produces a *more* robust response. People with natural immunity are getting reinfected at a higher rate than those with vaccine. Have you seen this work?
I really like your work and will translate this article, too. One thing i see differently is the existence of a pandemie by old definition as having a lot of deaths. In Germany in 2020 less people died than expected and hospitals were equally full as every year. I cannot find a single dataset that would tell me there was a killer virus in Germany in 2020 or 2021. And as you say the NPIs are not responsible for that. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0255540
It is so important that we speak truth, not skew data or report mis-information in fear of "vaccine hesitancy" or "Hospitals being over-run".
Nearly all hospitals in Australia were over-run pre-pandemic - all this virus has done is showcase that.
Conversation regarding building our immunity & better health systems never make it to the mainstream media because of aforementioned "fears", this has to stop if we are going to survive, especially the working class and poor.
thank you for your article
Thank you for this superb article. It confirmed my hypothesis regarding vaccines induced immunity.
Throughout the pandemic, I have been reading a lot of scientific paper on this subject including this recent one: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8358136/
This particular paragraph from the aforementioned article on mucosal immunity grab my attention and led me to conclude the anti-SARS-CoV-2 lasting immune cells elicited by the vaccines wouldn't know to migrate to the lung tissue and at the portals of pathogen entry after administration of the vaccines: "Paired studies of respiratory wash and blood samples in severe COVID-19 showed activated TRM T cells in the airways that do not correlate with systemic blood T cell responses, clearly suggesting that tissues, rather than blood, are where anti-SARS-CoV-2 lasting immune cells act [6]. Likewise, specific lung-resident memory B cells are formed early at the portals of pathogen entry following mucosal infection, and provide better protection than circulating memory cells."
Since biology is not my area of expertise, I was hoping one day to have an expert confirmed my hypothesis/educated guess. Again thank you very much for sharing your knowledge.
Thank you for this explanation. You have a great way of making a difficult subject understandable.
Wow. You made a complex concept understandable. And I STILL think you're a really smart guy.... and someone who understands the value of communication over academic prose. Thank you sir, this one's saved for future reference and education!
Long read but worth the time and efford
I would like to share positive feedback from my partners - thank you!
Thank you!
A question: is this analysis of the different types of immunity, & the effects of vaccines on immunity, in any way affected (or potentially affected) by recent observations from the UK Health Security Agency surveillance data that N antibody levels appear to be lower in individuals who acquire infection following 2 doses of vaccination? (Page 23 of week 42 UKHSA vaccine surveillance report, comments on Table 6.)
Thank you for this. It’s the most in-depth description I’ve found! Do you think there is any advantage in one dose of vaccine following confirmed infection and recovery?
Another eloquent one.
Another clear and very helpful article. The links provide additional useful information. Keep writing and posting.
Fantastic! I teach microbiology and I will be sharing this article with my students.
Thank you, I think the next step would be to introduce the offsetting risks associated with the new technology as its clear there are numerous injuries and deaths, many of which (the majority) are not reported accurately, or hidden. Then we start seeing the wood for the trees.
Thanks for the piece of "natural immunity" versus vaccination. Although your hunch has been that "natural immunity" should be more efficacious, this does not seem to square with the recent paper published in Science entitled "mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern."
https://www.science.org/doi/10.1126/science.abm0829
I look forward to reading your take on the work.
I do not fear at all the 'problem'
I fear the 'solution'.
I think you're absolutely right that we should take into account natural immunity (from prior infection) when assessing the current state of the pandemic. But that's different from using natural immunity as a strategy, right? Clearly, many, many more people would have become severely sick or died without the vaccines.
Also: more recent work suggests that the vaccine produces a *more* robust response. People with natural immunity are getting reinfected at a higher rate than those with vaccine. Have you seen this work?